目的 研究Meige综合征患者抑郁的发生情况及相关的因素.方法 应用汉密尔顿抑郁量表(HAMD)对62例Meige综合征患者和40例健康体检者进行抑郁评定.结果 62例Meige综合征患者中,有34例(54.8％)伴发抑郁,其中轻度抑郁30例(48.3％),中度抑郁4例(6.5％),无重度抑郁；对照组中4例(10％)伴发抑郁,其中轻度抑郁3例(7.5％),中度抑郁1例(2.5％),无重度抑郁,两组相比较差异有统计学意义(x2=20.91,P＜0.001);但是在程度上两组间无差异(x2=0.55,P＝0.45);Meige综合征患者抑郁组与非抑郁组HAMD各因子比较显示两组焦虑/躯体化、认知障碍、阻滞、睡眠障碍及绝望感差异均有统计学意义.结论 Meige综合征患者中有较高抑郁的发生率,主要表现为情绪低落、工作和兴趣减退、忧虑、睡眠障碍、迟缓、自卑感等,抑郁的发生与Meige综合征患者病程无关,而与性别相关,女性易发生.
Emotional disorder and related factors in patients with Meige syndrome
LONG Yu-zhou,LEI Jin,CHEN Yang
Objective To study the incidence of depression in Meige syndrome and associated factors. Methods Sixty-two Meige syndrome patients with depression and 40 healthy subjects as control were evaluated using Hamilton Depression Scale（HAMD）. Results Fifty-four point eight percent（34/ 62） of Meige syndrome pailents and 10% （4/40）of healthy subjects were found to have depression （H AMD score 8 or higher）, 48.3% （30/62）of Meige syndrome patients and 7.5%（3/40） of healthy subjects had mild depression（HAMD score between 8 and 20）, 6.5 % （4/62）of Meige syndrome patients and 2.5% （1/40） of healthy subjects were classified into moderately depressed range（ HAMD score between 21 and 35）. There were statistical differences in Meige syndrome group and healthy subjects group（ χ2=20.91 ,P -C 0. 001）. There was not statistical difference in severity. Additionally, there were statistical differences in anxiety/somatization, cognitive impairment, block, sleep disorder and despair between depression group and non--depression group. Conclusions The incidence of depression is higher in Meige syndrome. Manifestation of depression are anxiety, reduced interest in work, sleep disorders, retardedness,inferiority complex, etc. We found no evidence for an association of the depression with disease course in patients with Meige syndrome, but it is related to sex,easy to occur in females.