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甲基苯丙胺使用障碍者戒断期血清代谢 组学特征分析
彭素芳苏杭陈天真李晓彤阮晓璐赵敏
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目的 探索甲基苯丙胺使用障碍者戒断期外周血代谢组学特点。方法 2017 年7 月在上 海市高境强制隔离戒毒所招募戒断期甲基苯丙胺使用障碍者40 例,社会招募健康对照者40 名。采用非 靶向气相色谱-质谱联合技术,检测外周血清中代谢产物。结果 甲基苯丙胺使用障碍戒断期患者相 对于健康对照者,年龄及体重指数(BMI)差异无统计学意义(P> 0.05),但氨基酸代谢通路及嘌呤代谢通 路相关代谢产物发生明显改变[倍数变化(FC)> 1.5,P< 0.05]。结论 甲基苯丙胺对外周代谢产生的 影响持续存在,在戒断期仍可观察到氨基酸代谢及嘌呤代谢通路的异常。
基金项目:国家自然科学基金项目(81771436);国家自然科学基金联合基金重点项目(U1502228); 国家重点研发计划资助项目(2017YFC1310400);上海市精神卫生中心院级课题(2017-YJ-03)
Analysis of serum metabonomics in patients with methamphetamine induced withdrawal disorder innervous system
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Abstract:
Objective To explore the metabonomics characters of peripheral blood in withdrawal period of methamphetamine abusers. Methods A total of 40 abstinent methamphetamine abusers were recruited from Shanghai Gaojing Forced Isolation Detoxification Institute, and 40 health controls were recruited from social in July 2017. Gas chromatography- mass spectrometry technology was used to detect metabolic products in serum. Results Compared with heathy controls, the age and body mass index( BMI) of abstinent methamphetamine abusers were not significant different( P>0.05), but metabolic products in amino acid metabolic pathways and purine metabolic pathways were changed significantly( FC>1. 5, P<0. 05). Conclusions Methamphetamine abuse influences the metabolic process persistently, amino acid and purine metabolic disturbance still can be observed in the abstinent period.

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