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眼球运动联合平衡功能测试对帕金森病和进行性核上性麻痹的 鉴别诊断价值
孙卓钟文周银平王含陈霞
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目的 观察比较帕金森病(PD)和进行性核上性麻痹(PSP)患者的眼球运动和平衡特点。 方法 采用横断面调查研究方法,顺序入组PD 和PSP患者,对患者进行眼球水平运动和躯体摆动测试, 收集测试结果并比较组间以及与健康对照之间测试结果的差异。结果 入组18 例PD 患者[男11 例, 年龄67(60,71)岁],9 例PSP患者[男7 例,年龄74(66,78.5)岁]和44 名健康人[男15 名,年龄67.5(62, 71)岁]。分层回归分析结果提示,在控制了年龄和性别的潜在影响后,眼动指标和躯体摆动指标在健 康人和PD患者间的差异有统计学意义(P< 0.01),眼动指标在健康人和PSP患者间的差异有统计学意 义(P< 0.01),躯体摆动指标在健康人和PSP患者间的差异无统计学意义(P> 0.05),眼动指标和躯体摆 动指标在PD 患者和PSP患者间的差异无统计学意义(P> 0.05)。结论 眼动和躯体摆动指标相结合或 许有助于鉴别PD和PSP。
基金项目:国家自然科学基金面上项目(81673169);国家“十三五”重大新药创制专项基金资助项 目(2017ZX09304031-001);国家“十三五”重点研发计划项目(2016YFC0105904XHW)
Value of differential diagnosis of the combination of eye movement and body sway examination onParkinson disease and progressive supranuclear paralysis
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Abstract:
Objective To compare the characteristics of eye movement and body sway of patients with Parkinson disease( PD) and progressive supranuclear palsy( PSP). Methods A cross-sectional study was conducted in a sequential group of patients with PD and PSP. The patients were tested for the horizontal movement of the eyeball and the somatic swinging. Collect the results, and compare the differences between PD group, PSP group, and that of the health group. Results PD group consisted of 18 PD patients[ male: 11, age: 67 (60, 71) years dd]. PSP group consisted of 9 patients with PSP[ male: 7, age: 74( 66, 78.5)years old]. Healthy group consists of 44 healthy people[ male: 15, age: 67.5( 62, 71)years old]. The results of hierarchical regression analysis showed that the difference of eye movement index and somatic swinging index between healthy people and PD patients was statistically significant( P< 0.01) after controlling the potential effects of age and sex. The difference of eye movement index between healthy people and PSP patients was statistically significant( P <0.01). There was no significant difference of the body swinging index between healthy people and PSP patients( P > 0.05). There was no statistical significance of either eye movement index or body swinging index between the PD patients and the PSP patients( P>0.05). Conclusions The combination of eye movement and body sway examinations might be helpful to identify PSP from PD.

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