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电针刺激迷走神经对青少年抑郁症患者炎性因子 表达水平的影响
杨超杨晓莹张莉王媛王艳杨萍
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目的 探讨电针刺激迷走神经对青少年抑郁症患者临床疗效及炎性因子表达水平的影 响。方法 纳入78 例青少年抑郁患者,随机分为试验组(电针刺激迷走神经+舍曲林,40 例)和对照组 (舍曲林,38 例),分别在治疗前及治疗4 周后进行评估。采用阳性与阴性症状量表(PANSS)、HAMD-17 进 行疗效评估,ELISA 方法检测IL-1α、TNF-α、IL-6、IL-2 炎性因子表达水平。结果 治疗4 周后试验组 有效率80.0%(32/40),对照组有效率57.9%(22/38),差异有统计学意义(χ2=4.470,P=0.034);两组PANSS 阴性因子、一般精神病理及总分、HAMD-17 总分较其治疗前均有所下降(P< 0.05);且试验组PANSS 一 般精神病理及总分、HAMD-17 总分低于对照组(P< 0.05)。试验组IL-1α、TNF-α、IL-6、IL-2 较治疗前、 对照组治疗后均明显降低(P< 0.05)。结论 电针刺激迷走神经对青少年抑郁症状有改善作用,可能与 降低炎性因子水平有关。
基金项目:乌鲁木齐市卫生计生委科技计划项目(201822);湖南省科技创新计划项目(2017SK50313)
Effect of vagus nerve stimulation by clectroacupuncture on the expression level of inflammatory factorsin adolescent depression patients
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Abstract:
Objective To explore the effects of vagus nerve stimulation by electroacupuncture on clinical efficacy and expression level of inflammatory factors in adolescent depression patients. Methods A total of 78 adolescent depression patients were randomly divided into experimental( vagus nerve stimulation by electroacupuncture + Sertraline, n=40) and control group( Sertraline, n=38). All the patients were evaluated at the baseline and 4 weeks after treatment. The Positive and Negative Syndrome Scale( PANSS) and Hamilton Depression Scale( HAMD-17) were applied to evaluate efficacy. ELISA was used to detect the expression level of IL-1α,TNF-α,IL-6,IL-2. Results The effective rate of the experimental group was 80.0%( 32/40), and that of the control group was 57.9%( 22/38). The difference was statistically significant( χ2=4.470,P=0.034). The negative factor, the general psychopathology and the total score of PANSS and the total score of HAMD-17 of the 2 groups all decreased than before treatment( P<0.05). The general psychopathology and the total score of PANSS and the total score of HAMD-17 of the experimental group were lower than those of the control group (P< 0.05). IL-1α,TNF-α,IL-6, IL-2 of the experimental group decreased than before the treatment and those of the control group after treatment( P< 0.05). Conclusions Vagus nerve stimulation by electroacupuncture can improve depressive symptoms in adolescents, possibly by reducing the level of inflammatory factors.

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