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精神分裂症的动物模型研究进展
王也夫吴桐李平焦宇赵容杰崔光成
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精神分裂症是一种在认知、情感、行为、社会功能等多方面存在障碍的慢性重性精神疾病。 精神分裂症动物模型被广泛应用于病因机制、药物作用机理乃至新药开发等研究。良好的动物模型构 建将有利于解决疾病研究中的工作难题。现对精神分裂症动物模型的类型与精神分裂症发病机制的关 联进行综述,为研究精神分裂症的动物实验研究提供文献依据。
基金项目:黑龙江省教育厅2016 年度基本科研业务费项目计划(2016-KYYWF-0883)
Animal models and etiology of schizophrenia
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Abstract:
Schizophrenia is a kind of chronic serious mental disease with impaired cognitive, emotional, behavioral and social functions. Animal models of schizophrenia have been widely used in the study of etiology, mechanism of drug action and new drug development. Good animal model construction will help to solve the difficult problems in disease research. This article reviews the relationship between the types of animal models of schizophrenia and the pathogenesis of schizophrenia, and provides literature basis for the study of animal experimental studies of schizophrenia

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